Wytheville is a town in, and the county seat of, Wythe County, in western Virginia, United States. It is named after George Wythe, a signer of the United States Declaration of Independence, and mentor to Thomas Jefferson. Wytheville's population was 8,211 at the 2010 census.

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George Wythe High School is located 2 miles off Interstate 81 on the West Side of town.